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The U.S. Food and Drug Administration has approved Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment selection for chronic weight-loss in addition to a reduced-calorie diet and exercise. Using two separate drugs to lose weight naturally can be very effective you can find combinations in front of the FDA now awaiting approval. When dealing with weight-loss and the people that go through it you need to err to the side of caution and permit the FDA do its job and demand some investigation be done so the public is aware of the side effects and dangers of the medications before we bring them. Keep in mind that drug companies are in business to generate money and that they would say everything to keep people on the medications. Researchers discovered that participants investing in this drug for the year, dropped excess weight within a month and have kept the extra weight off during the entire 56 weeks of the study. Contrave is really a combination of the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs which are made up of more than one active ingredient, which might make them far better and safer. Combo-pilling is the newest fad or better yet the newest to come under scrutiny and thus it is just more publicly known although in the past, comb-pilling for weight loss has been around since the eighties. The biggest reason that using a combination of pills has become popular will be the fact that since right now there aren't any long term prescription weight loss supplements that have been approved by the FDA aside from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications and some of the combinations are already rejected or have yet to be approved by the FDA. Seizures are a side effect with Contrave and shouldn't be taken in people with seizure disorders. The drug can also raise hypertension and heartrate, and really should not be used in people who have a history of cardiac arrest or stroke in the earlier six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise blood pressure level and heartbeat and must stop used in patients with uncontrolled high blood pressure level, and also by you are not heart-related and cerebrovascular (circulatory dysfunction impacting mental performance) disease. Patients using a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes having a boxed warning to alert medical researchers and patients for the increased chance of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for smoking cessation. The most common negative effects with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.

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